Y. Kawaguchi, M. Kiyokawa, D. Yamasaki, M. Watabe, S. Shiomoto, Y. Mimori-Kiyosue, S. Arakawa, M. Tanaka, M. Okumura, S. Futaki, Burst-like intracellular antibody infusion via membrane-permeabilizing peptide microcondensates, Nature Commun., accepted.(2026) DOI: 10.6084/m9.figshare.30284182
M. Nakahata, C. Kojima, Y. Tanaka, K. Hirohata, A. Matsumoto, S. Morita, Y. Takashima, M. Tanaka, T. Kato,Hydration-state-dependent phase behavior of poly(N-isopropylacrylamide): Role of bound water revealed by lower-temperature differential scanning calorimetry, Polym. J., accepted.
R. Kaizu, A. Yamamoto, M. Tanaka, T. Hayashi, Time-Dependent UV/Ozone Treatment Modulates Platelet Adhesion on Polystyrene and Cyclo-Olefin Polymer through Fibrinogen Orientation, Langmuir, 42, 27841–27850 (2026). DOI: 10.1021/acs.langmuir.6c02349
K. Maeda, H. Terao, K. Kazuno, P. Wen, A. Yamamoto, Y. Tanaka, H. Tsuchiya, M. Tanaka, Poly(2-methoxyethyl acrylate) analog coatings enhance long-term endothelialization and support blood-compatible healing of vascular grafts in nonhuman primate models, Biomater. Adv., in press. DOI : 10.1016/j.bioadv.2026.215105
T. Ikegami, Y. Kurihara, C. Ushiku, T. Anada, K. Morioka, Y. Kado, K. Nishida, N. Shiraishi, B. Gao, H. Masumoto, Y. Honda, K. Yonemoto, T. Ishimoto, M. Saito, M. Tanaka, Multifunctional poly(2-methoxyethyl acrylate) coatings with intermediate water on titanium implants enhance osseointegration via accelerated bone maturation, Biomater. Adv., 188, 215034.(2026) DOI: 10.1016/j.bioadv.2026.215034
Y. Kitsuki, Y. Tanaka, S. Endo, Y. Zhang, M. Nagao, H. Matsumoto, M. Hishida, T. Yamaguchi, M. Tanaka, Y. Miura, Hydration effect of glycopolymers on lectin recognition, Biomacromolecules, 27 (8), 5546–5557 (2026). DOI: 10.1021/acs.biomac.6c00850
H. J. Lee, Y. Tanaka, M. Tanaka, K. Fukushima, Hydrolytic behavior of dihydroxy-functionalized poly(trimethylene carbonate) analogs with amide linkers, Polym. J., 58, 1173–1184 (2026). DOI：10.1038/s41428-026-01226-w
H. Seto, D. Murakami, T. Tominaga, S. Shiomoto, M. Tanaka, Dynamics of Intermediate Water in Biocompatible Poly(2-methoxyethyl acrylate) Revealed by Quasi-Elastic Neutron Scattering, J. Phys. Chem., B,130, 6988-6995 (2026). DOI: 10.1021/acs.jpcb.6c02094.
Y. Zhang, Y. Tanaka, S. Honda, M. Tanaka, Hydration and Entanglement Contrasts Between Dry and Wet States in Blood-Compatible Poly(2-methoxyethyl acrylate), Journal of Inorganic and Organometallic Polymers and Materials, in press. (2026) DOI : 10.21203/rs.3.rs-9439122/v1
Y. Sekizawa, S. Shiomoto, T. Isono, K. Tajima, M. Tanaka, T. Satoh, K. Ijiro, H. Mitomo, Polymer Brush Morphology-Directed Orientation and Arrangement of Gold Nanorod Arrays, Chem. Mater., 38(8), 4343-4352 (2026). DOI : 10.1021/acs.chemmater.6c00538
I. S. Cho, M. Tanaka, Designing Interfacial Hydration in Natural Polymers via Intermediate Water, MRS Commun., 16, 260-270 (2026). DOI : 10.1557/s43579-026-00925-y
M. Tanaka, S. Morita, T. Hayashi, Interfacial Water States and the Biocompatibility of Biomaterials: The Role of Intermediate Water, Special issue on “Biocompatible Polymers: Fundamentals and Applications”, Polym. J. 58, 343–356 (2026). DOI: 10.1038/s41428-025-01139-0
M. Mabrouk, S. Shiomoto, S-n. Nishimura, H. H. Beherei, E. Alzahrani, Y. Tanaka, M. Tanaka, Injectable composite gels containing magnesium phosphate for bone regeneration: Analysis of hydration and in vivo study, Biomaterials Adv., 180, 214606 (2026). DOI: 10.1016/j.bioadv.2025.214606
J. Li, K. Toh, P. Wen, X. Liu, A. Dirisala, H. Guo, J.F.R. Van, Guyse, S. Abbasi, H. Kinoh, Y. Anraku, Y. Mochida, H. Kinoh, H. Cabral, M. Tanaka, K. Kataoka, Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer, Nature Biomed. Eng. 10, 1445–1465 (2026). DOI:10.1038/s41551-025-01534-1
X. Li, L. Sun, X. Liu, P. Wen, Y. Zhang, Y. Mu, M. Tanaka, Y. Cheng, J. Li, W. Zhou,Enzyme-Powered Micellar Nanoreactors Enable Tumor-Specific, Cascade-Amplified Prodrug Activation for Synergistic Oxidation–Chemo–Immunotherapy, J. Control. Release, 389, 114363 (2026). DOI:10.1016/j.jconrel.2025.114363 2025
S. Honda, Y. Zhang, M. Tanaka, Light-driven rheological modulation of solventless polymer networks enabled by precisely architected flexible star polysiloxanes, Chem. Commun., 61, 19112-19115 (2025). DOI:10.1039/D5CC04840K
M. Kawahara, K. Miyazaki, T. Anada, S, Kobayashi, M. Tanaka, Engineering Three-Dimensional Cellular Organization by Regulating Bound Water-Mediated Cell–Substrate Interactions for Disease Modeling, ACS Omega, 10(45), 54951–54966 (2025). DOI : 10.1021/acsomega.5c09030
Q. He, J. He, P. Wen, H. Guo, M. Tanaka, S. Luo, J. Li, Y. Liu, L. Wen, C. Yao, NIR-Activatable Aza-BODIPY Nanoparticles for Photoacoustic Imaging and Synergistic NO–Photothermal Cancer Therapy, Biomater. Sci., 13, 5369-5381 (2025). DOI: 10.1039/D5BM00937E
Y. Ohnishi, D. Setoyama, H. Miwa, N. Koitabashi, R. Ogasawara, S. Kitada, N. Matoba, T. Ayano, K. Hiramoto, R. Yasui, Y. Sugiura, T. Anada, K. Ino, H. Matsuda, T. Noma, S. Nonaka, T. Izumi, M. Kurabayashi, M. Suematsu, Y. Kunisaki, M. Yanagita, H. Imamura, M. Yamamoto, AVID mouse: A versatile platform for real-time, multiscale ATP imaging and spatial systems metabolism analysis in living mice, Cell Rep. 44(9), 116246 (2025). DOI: 10.1016/j.celrep.2025.116246
S. Kobayashi, Y. Okazaki, M. Tanaka, Impact of Side Chain Carbonyl Group Position on Polymer Hydration, Dynamics, and Antithrombotic Activity: A Systematic Study of Structure-Property Relationships, Macromolecules, 58(16), 8821-8832 (2025). DOI: 10.1021/acs.macromol.5c01688
K. Uchida, N. Shimokawa, R. Wakabayashi, S. Shiomoto, K. Toyofuku, N. Ogushi, M. Goto, M. Tanaka, M. Takagi, N. Kamiya, Exploring the significance of palmitoylation using an artificial protein lipidation system, RSC Chem. Biol., 6, 1483-1496 (2025). DOI: 10.1039/D5CB00143A
K. Kitagawa, S. Kobayashi, Y. Miura, M. Tanaka, H. Ise, Targeting and Suppression of Survivin in Cancer Cells Based on the Interaction of Cell Surface Vimentin with N-Acetylglucosamine-Bearing Polymers, ACS Omega, 10(33), 37162-37175 (2025). DOI: 10.1021/acsomega.5c02098
T. Anada, M. Kawahara, T. Shimada, R. Kuroda, H. Okamura, D. Setoyama, F. Nagatsugi, Y. Kunisaki, E. K. Nakadai, S. Kobayashi, M.Tanaka, A nucleic acid prodrug that activates mitochondrial respiration, promotes stress resilience, and prolongs lifespan, J. Am. Chem. Soc., 147(25), 22161-22175 (2025). DOI: 10.1021/jacs.5c06772
L. Sun, Q. Pan, Y. Li, Y. Mu, Y. Cheng, Y. Feng, M. Tanaka, P. Wen, X. Liu, Semi-permeable polymer vesicle-based prooxidative and lactate-depleting nanoreactors with sustained activity against pancreatic cancer, Front. Bioeng. Biotechnol., 13, 1626927 (2025). DOI: 10.3389/fbioe.2025.1626927
B. Fei, H. Wang, Y. Ding, N. Shao, P. Wen, Y. Cao, J. Li, M. Tanaka, Z. Wang, S. Li, Reprogramming Cellular Senescence of Hepatic Stellate Cells to Combat Liver Fibrosis by Targeted Nanodrugs, Materials Today Bio, 33, 101996 (2025). DOI : 10.1016/j.mtbio.2025.101996
M. A. Saleh, Y. Higuchi, S. Shiomoto, T. Anada, M. Hishida, M. Tanaka, Effect of Zwitterionic Monomer Polymerization on Water Dynamics: A Molecular Dynamics Simulation Study Supported by Differential Scanning Calorimetry and Terahertz Spectroscopy, Polym. J., 57, 1127–1139 (2025). DOI : 10.1038/s41428-025-01066-0
Y. Kawai, J. Park, R. Motokawa, R. Ikura, S. Murayama, K. Yamaoka, Y. Fujii, Y. Ikemoto, M. Tanaka, G. Matsuba, T. Kato, Y. Takashima, Effects of the Hydration States of Water Molecules on the Mechanical Properties of Dual Movable Crosslinked Polymeric Gels, ACS Appl. Polym. Mater., 7(12), 7767-7776 (2025). DOI : 10.1021/acsapm.5c00270
P. Wen, A. Dirisala, H. Guo, X. Liu, S. Kobayashi, H. Kinoh, T. Anada, M. Tanaka, K. Kataoka, J. Li, Engineering Durable Antioxidative Nanoreactors as Synthetic Organelles for Autoregulatory Cellular Protection Against Oxidative Stress, J. Controlled Release, 382, 113683 (2025). DOI: 10.1016/j.jconrel.2025.113683
M. Nakayama, T. Kanno, A. Kikuchi, Y. Tanaka, T. Anada, M. Tanaka, T. Okano, Visible-light-triggered recovery of biologically intact cells using smart fluoropolymer-nanocoated materials, J. Controlled Release, 382, 113653 (2025). DOI: 10.1016/j.jconrel.2025.113653
I. S. Cho, S. Shiomoto, N. Yukawa, Y. Tanaka, K.M. Huh, M. Tanaka, The Role of Intermediate Water in Enhancing Blood and Cellular Compatibility of Chitosan-Based Biomaterials, Langmuir, 41(12), 8301–8311 (2025). DOI: 10.1021/acs.langmuir.5c00125
K. Yokota, S. Usuda, T. Nishimura, R. Takahashi, Y. Taoka, S. Kobayashi, M. Tanaka, K. Matsumura, S. Yusa, Self-Assembly and Drug Encapsulation Properties of Biocompatible Amphiphilic Diblock Copolymers, Langmuir, 41(1), 765–773 (2025). DOI: 10.1021/acs.langmuir.4c04048 2024
T. Anada, M. Kawahara, T. Shimada, R. Kuroda, E. Kage-Nakadai, S. Kobayashi, M. Tanaka, A nucleic acid prodrug activates mitochondrial respiration and extends lifespan, bioRxiv (2024). DOI：10.1101/2024.11.16.623599
S. Nishimura, N. Kurahashi, S. Shiomoto, Y. Harada, M. Tanaka, Effects of Hydration Water on Bioresponsiveness of Polymer Interfaces Revealed by Analysis of Linear and Cyclic Polymer–Grafted Substrates, Soft Matter, 2024, 20, 9454-9463 (2024). DOI：10.1039/D4SM00977K
T. Suzuki, H. Konishi, A. Suzuki, T. Katsumata, Y. Fukuda, K. Miyamoto, T. Ise, Y. Tanaka, A. Yamamoto, P. Wen, S. Shiomoto, M. Tanaka, S. Nemoto, Role of intermediate water in reducing postsurgical intrapericardial adhesion, Surgery Today, 555, 847–856 (2025). DOI : 10.1007/s00595-024-02953-4
B. Fei, Y. Zhao, J. Wang, P. Wen, J. Li, M. Tanaka, S. Li, Z. Wang, Leveraging Adrenergic Receptor Blockade for Enhanced Nonalcoholic Fatty Liver Disease Treatment via a Biomimetic Nanoplatform, J. Nanobiotechnol., 22(1), 591 (2024). DOI：10.1186/s12951-024-02864-z
M. Najmina, R. Shimazui, S. Kobayashi, H. Takata, M. Shibata, K. Ishibashi, A. Kishimura, Y. Shiota, D. Ida, T. Shimizu, T. Ishida, Y. Katayama, M.Tanaka, T. Mori, A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome, Pharmaceutics, 16(10), 1271 (2024). DOI：10.3390/pharmaceutics16101271
Y. Higaki, T. Masuda, S. Shiomoto, Y. Tanaka, H. Kiuchi, Y. Harada, M. Tanaka, Pronounced Cold Crystallization and Hydrogen Bonding Distortion of Water Confined in Microphases of Double Zwitterionic Block Copolymer Aqueous Solutions, Langmuir, 40(37), 19612-19618 (2024). DOI：10.1021/acs.langmuir.4c02254
K. Nishida, R. Ikura, K. Yamaoka, O. Urakawa, T. Konishi, T. Inoue, G. Matsuba, M. Tanaka, Y. Takashima, Relation between the Water Content and Mechanical Properties of Hydrogels with Movable Cross-Links, Macromolecules, 57(16), 7745-7754 (2024). DOI：10.1021/acs.macromol.4c00732
S. Zuo, Z. Wang, X. Jiang, Y. Zhao, P. Wen, J. Wang, J. Li, M. Tanaka, D. Shao, Y. Zhang, Z. Wang, Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain, Biomaterials, 309, 122603 (2024). DOI: 10.1016/j.biomaterials.2024.122603
M. Okada, S. C. Xie, Y. Kobayashi, H. Yanagimoto, D. Tsugawa, M. Tanaka, T. Nakano, T. Fukumoto, T. Matsumoto, Water-mediated on-demand detachable solid-state adhesive of porous hydroxyapatite for internal organ retractions, Adv. Healthcare Mater., 13(19), 2304616 (2024). DOI: 10.1002/adhm.202304616
Y. Higuchi, M. A. Saleh, T. Anada, M. Tanaka, M. Hishida, Rotational Dynamics of Water near Osmolytes by Molecular Dynamics Simulations, J. Phys. Chem. B, 128(20), 5008–5017(2024). DOI : 10.1021/acs.jpcb.3c08470
T. Kikuchi, T. Tominaga, D. Murakami, N. Souza, M. Tanaka, H. Seto, Detailed dynamical features of the slow hydration water in the vicinity of poly(ethylene oxide) chains, J. Chem. Phys., 160(6), 064902 (2024). DOI：10.1063/5.0185432
K. Fukushima, S. Hakozaki, R. Lang, Y. Haga, S. Nakai, A. Narumi, M. Tanaka, T. Kato, Hydrolyzable and biocompatible aliphatic polycarbonates with ether functionalized side chains attached via amide linker, Polym. J. 56, 431–442 (2024). DOI：10.1038/s41428-023-00874-6
K. Fujiura, M. Naito, Y. Tanaka, M. Tanaka, Y. Nakanishi, H. Ejima, L. Negishi, T. Kujirai, H. Kurumizaka, S. Ohta, K. Miyata, Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol) , J. Appl. Polym. Sci. 141(11) e55044 (2024). DOI：10.1002/app.55044
T. Miyano, Y. Ayukawa, T. Anada, I. Takahashi, H. Furuhashi, S. Tokunaga, A. Hirata, N. Nakashima, K. Kato, H Fukuda, Association between reduced posterior occlusal contact and Alzheimer’s disease onset in older Japanese adults: results from the LIFE Study, J. Alzheimers Dis., 97(2), 871-881 (2024). DOI : 10.3233/JAD-230449
N. Hayakawa, M. Nishiura, T. Anada, S. Kobayashi, T. Sawada, T. Serizawa, M. Tanaka, Suspension Culture System for Isolating Cancer Spheroids using Enzymatically Synthesized Cellulose Oligomers, ACS Appl. Bio Mater., 7(1) 306-314 (2024). DOI：10.1021/acsabm.3c00901
R. Wulandari, Y. Kusumastuti, A. Prasetya, Y. A. Purwestri, H. T. B. M. Petrus, A. Idrus, M. Tanaka, Antibacterial activity of copper nanoparticles (CuNPs) by the chemical reduction method, AIP Conf. Proc. 3073, 040001 (2024). DOI: 10.1063/5.0193978
2023
D. Miyake, J. He, F. Asai, M. Hara, T. Seki, S. Nishimura, M. Tanaka, Y. Takeoka, Optically Transparent and Color-Stable Elastomer with Structural Coloration under Elongation, Langmuir, 39(49) 17844-17852 (2023). DOI：10.1021/acs.langmuir.3c02442
T. Ota, V. Montagna, Y. Higuchi, T. Kato, M. Tanaka, H. Sardon, K. Fukushima, Organocatalyzed ring-opening reactions of γ-carbonyl-substituted ε-caprolactones, RSC Adv., 13(40), 27764-27771 (2023). DOI：10.1039/d3ra01025b
S. Nishimura, M. Tanaka, The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update, Bull. Chem. Soc. Jpn., 96(9), 1052-1070 (2023) . Account/Review for Memorial Collection for CSJ/OUP Co-Operative Publication Account/Review for Controlled Chemical Construction (C3) for Advanced Functions DOI : 10.1246/bcsj.20230168
R. Koguchi, K. Jankova, Y. Tanaka, A. Yamamoto, D. Murakami, Q. Yang, B. Ameduri, M. Tanaka, Altering the Bio-inert Properties of Surfaces by Fluorinated Copolymers of mPEGMA, Biomater. Adv., 153, 213573 (2023). DOI: 10.1016/j.bioadv.2023.213573
Y. Higaki, H. Toyama, T. Masuda, S. Kobayashi, M. Tanaka, Microphase Separation of Double-Hydrophilic Poly(carboxybetaine acrylate)-Poly(2-methoxyethyl acrylate) Block Copolymers in Water, Polym. J., 55, 1357-1365 (2023). DOI: 10.1038/s41428-023-00831-3
S. Kobayashi, M. Tanaka, Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes, Mol. Syst. Des. Eng., 8, 960-991 (2023). DOI: 10.1039/d3me00063j
A. Kumar, A. Sood, G. Agrawal, S. Thakur, V. K. Thakur, M. Tanaka, Y. K. Mishra, G. Christie, E. Mostafavi,R. Boukherroub, D. W. Hutmacher, S. S. Han, Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review, Int. J. Biol. Macromol., 247, 125606 (2023). DOI: 10.1016/j.ijbiomac.2023.125606
P. Wen, W. Ke, A. Dirisala, K. Toh, M. Tanaka, J. Li, Stealth and pseudo-stealth nanocarriers, Adv. Drug Delivery Rev., 198, 114895 (2023). DOI: 10.1016/j.addr.2023.114895
H. Kurita, S. Kobayashi, T. Anada, M. Tanaka, M. Todo, Cellular characterization of hiPS-CMs cultured on PMEA analogous polymers with different bound water content, Engineering Sciences Reports, Kyushu University, 45(1), 1-6 (2023). https://www.tj.kyushu-u.ac.jp/g_public/img/report_img/45-1.pdf
R. Saeki, S. Kobayashi, R. Shimazui, T. Nii, A. Kishimura, M. Tanaka, T. Mori, Y. Katayama, Characterization of polypropyleneimine as an alternative transfection reagent, Anal. Sci., 39, 1015-1020 (2023). DoI: 10.1007/s44211-023-00284-x
M. Nomura, Y. Yokoyama, D. Yoshimura, Y. Minagawa, A. Yamamoto, Y. Tanaka, N. Sekiguchi, D. Marukawa, M. Ichihara, H. Itakura, K. Matsumoto, Y. Morimoto, H. Tomihara, A. Inoue, T. Ogino, N. Miyoshi, H. Takahashi, H. Takahashi, M. Uemura, S. Kobayashi, T. Mizushima, T. Anada, M. Mori, Y. Doki, M. Tanaka, H. Eguchi, H. Yamamoto, Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates, Int. J. Mol. Sci., 24(4), 3949 (2023). DOI:10.3390/ijms24043949
T. Ohta, M. Tanaka, S. Taki, H. Nakagawa, S. Nagase, Honeycomb-like Structured Film, a Novel Therapeutic Device, Suppresses Tumor Growth in an In Vivo Ovarian Cancer Model, Cancers, 15(1), 237 (2023). DOI:10.3390/cancers15010237
M. Mabrouk, H. H. Beherei, S. Shiomoto, Y. Tanaka, L. Osama, M. Tanaka, Effect of titanium-doped bioactive glass on poly(2-hydroxyethyl methacrylate) hydrogel composites: bioactivity, intermediate water, cell proliferation, and adhesion force, Ceram. Int., 49(9), 13469-13481 (2023). DOI:10.1016/j.ceramint.2022.12.221
C. Kojima, Y. Suzuki, Y. Ikemoto, M. Tanaka, A. Matsumoto, Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy, Polym. J., 55, 63–73 (2023). DOI:10.1038/s41428-022-00700-5
T. Miyano, T. Anada, M. Furuta, Y. Yamashita,Prefectural Differences in Chewing Ability in Questionnaire for Specific Health Checkup and Exploring of Related Factors, Journal of Dental Health, 73(2), 103-111 (2023). DOI: 10.5834/jdh.73.2_103
2022
T. Serizawa, S. Yamaguchi, M. Amitani, S. Ishii, H. Tsuyuki, Y. Tanaka, T. Sawada, I. Kawamura, G. Watanabe, M. Tanaka, Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl β-celluloside assemblies, Colloids Surf., B, 220, 112898 (2022). DOI:10.1016/j.colsurfb.2022.112898
S. Kobayashi, A. Sugasaki, Y. Yamamoto, Y. Shigenoi, A. Udaka, A. Yamamoto, M. Tanaka, Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion, ACS Biomater. Sci. Eng., 8(10), 4547-4556 (2022). DOI:10.1021/acsbiomaterials.2c00662
J. Park, T. Ueda, Y. Kawai, K. Araki, M. Kido, B. Kure, N. Takenaka, Y. Takashima, M. Tanaka, Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate, RSC Advances, 12(43), 27912-27917 (2022). DOI:10.1039/d2ra04885j
M. A. Haque, D. Murakami, M. Tanaka, Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel, Surfaces, 5(3), 365-382 (2022). DOI:10.3390/surfaces5030027
Y. Watanabe, S. Takaoka, Y. Haga, K. Kishi, S. Hakozaki, A. Narumi, T. Kato, M. Tanaka, K. Fukushima, Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates, Polym. Chem., 13(36), 5193-5199 (2022). DOI:10.1039/d2py00705c
M. A. Haque, D. Murakami, T. Anada, M. Tanaka, Poly(2-Methoxyethyl Acrylate) (PMEA)-Coated Anti-Platelet Adhesive Surfaces to Mimic Native Blood Vessels through HUVECs Attachment, Migration, and Monolayer Formation, Coatings, 12(6), 869 (2022). DOI:10.3390/coatings12060869
S. Shiomoto, K. Inoue, H. Higuchi, S. Nishimura, H. Takaba, M. Tanaka, M. Kobayashi, Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers, Biomacromolecules, 23(7), 2999–3008 (2022). DOI:10.1021/acs.biomac.2c00484
M. Mabrouk, H. H. Beherei, Y. Tanaka, M. Tanaka, Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode, Biomater. Adv., 138, 212965 (2022). DOI:10.1016/j.bioadv.2022.212965
J.-J Huang, C.-H. Lin, Y. Tanaka, A. Yamamoto, S.-C Luo, M. Tanaka, Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications, Adv. Mater. Interfaces, 2200707 (2022). DOI:10.1002/admi.202200707
Y. Ikemoto, Y. Harada, M. Tanaka, S. Nishimura, D. Murakami, N. Kurahashi, T. Moriwaki, K. Yamazoe, H. Washizu, Y. Ishii, H. Torii, Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions, The Journal of Physical Chemistry B, 126(22), 4143-4151 (2022). DOI:10.1021/acs.jpcb.2c01702
S. Nishimura, K. Nishida, S. Shiomoto, M. Tanaka, Surfactant-free suspension polymerization of hydrophilic monomers with an oil-in-water system for the preparation of microparticles toward the selective isolation of tumor cells, Mater. Adv., 3(12), 5043-5054 (2022). DOI:10.1039/D2MA00129B
K. Nishida, T. Anada, M. Tanaka, Roles of interfacial water states on advanced biomedical material design, Adv. Drug Delivery Rev., 186, 114310 (2022). DOI:10.1016/j.addr.2022.114310
K. Nishida, K. Baba, D. Murakami, M. Tanaka, Nanoscopic analyses of cell-adhesive protein adsorption on poly(2-methoxyethyl acrylate) surfaces, Biomater. Sci., 10(11), 2953-2963 (2022). DOI:10.1039/D2BM00093H
S. Nishimura, K. Nishida, T. Ueda, S. Shiomoto, M. Tanaka, Biocompatible poly(N-(ω-acryloyloxy-n-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(N-isopropylacrylamide), Polym. Chem., 13(17), 2519–2530 (2022). DOI:10.1039/d2py00154c
M. Hishida, R. Anjum, T. Anada, D. Murakami, M. Tanaka, Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins, J. Phys. Chem. B, 126(13), 2466–2475(2022). DOI:10.1021/acs.jpcb.1c10634
T. Tominaga, M. Hishida, D. Murakami, Y. Fujii, M. Tanaka, H. Seto, Experimental Evidence of Slow Mode Water in the Vicinity of Poly(ethylene oxide) at Physiological Temperature, J. Phys. Chem. B, 126(8), 1758–1767 (2022). DOI:10.1021/acs.jpcb.1c09044
K. Nishida, S. Nishimura, M. Tanaka, Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer, Biomacromolecules, 23(4), 1569–1580 (2022). DOI:10.1021/acs.biomac.1c01343
K. Nishida, S. Sekida, T. Anada, M. Tanaka, Modulation of Biological Responses of Tumor Cells Adhered to Poly(2-methoxyethyl acrylate) with Increasing Cell Viability under Serum-Free Conditions, ACS Biomater. Sci. Eng., 8(2), 672–681 (2022). DOI:10.1021/acsbiomaterials.1c01469
D. Murakami, K. Yamazoe, S. Nishimura, N. Kurahashi, T. Ueda, J. Miyawaki, Y. Ikemoto, M. Tanaka, Y. Harada, Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation, Langmuir, 38(3), 1090-1098 (2022). DOI:10.1021/acs.langmuir.1c02672
D. Murakami, S. Nishimura, Y. Tanaka, M. Tanaka, Observing the Repulsion Layers on Blood-compatible Polymer-grafted Interfaces by Frequency Modulation Atomic Force Microscopy, Biomater. Adv., 133, 112596 (2022). DOI:10.1016/j.msec.2021.112596
K. Fukushima, K. Matsuzaki, M. Oji, Y. Higuchi, G. Watanabe, Y. Suzuki, M. Kikuchi, N. Fujimura, N. Shimokawa, H. Ito, T. Kato, S. Kawaguchi, M. Tanaka, Anisotropic, Degradable Polymer Assemblies Driven by a Rigid Hydrogen-Bonding Motif That Induce Shape-Specific Cell Responses, Macromolecules, 55(1), 15–25 (2022). DOI:10.1021/acs.macromol.1c01894
S. Nishimura, K. Nishida, M. Tanaka, A β-hairpin peptide with pH-controlled affinity for tumor cells, Chem. Commun., 58(4), 505-508 (2022). DOI:10.1039/D1CC06218B
R. Koguchi, K. Jankova, M. Tanaka, Fluorine-containing bio-inert polymers: Roles of intermediate water, Acta Biomater., 138(15), 34-56 (2022). DOI:10.1016/j.actbio.2021.10.027
C. Ueda, J. Park, K. Hirose, S. Konishi, Y. Ikemoto, M. Osaki, H. Yamaguchi, A. Harada, M. Tanaka, G. Watanabe, Y. Takashima, Behavior of supramolecular cross-links formed by host-guest interactions in hydrogels responding to water contents, Supramol. Mater., 1, 100001 (2022). DOI:10.1016/j.supmat.2021.100001
2021
Y. Asawa, K. Nishida, K. Kawai, K. Domae, H. S. Ban, A. Kitazaki, H. Asami, J. Kohno, S. Okada, H. Tokuma, D. Sakano, S. Kume, M. Tanaka, H. Nakamura, Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation, Bioconjugate Chem., 32(11), 2377–2385 (2021). DOI:10.1021/acs.bioconjchem.1c00431
W. Lee, S.-H. Jeong, Y.-W. Lim, H. Lee, J. Kang, H. Lee, l. Lee, H-S. Han, S. Kobayashi, M. Tanaka, B.-S. Bae, Conformable microneedle pH sensors via the integration of two different siloxane polymers for mapping peripheral artery disease, Sci. Adv., 7(48), eabi6290 (2021). DOI:10.1126/sciadv.abi6290
T. Ishizawa, N. Makino, Y. Kakizaki, A. Matsuda, Y. Toyokawa, S. Ooyama, M. Tanaka, Y. Ueno, Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo, PLoS ONE, 16(9), e0257828 (2021). DOI:10.1371/journal.pone.0257828
R. Chang, E. Angelo Q. Mondarte, D. Palai, T. Sekine, A. Kashiwazaki, D. Murakami, M. Tanaka, T. Hayashi, Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis, Front. Chem., 9, 748017 (2021). Part of the Research Topic: Interfacial Water: A Physical Chemistry Perspective, Volume II DOI:10.3389/fchem.2021.748017
Y. Fujii, T. Tominaga, D. Murakami, M. Tanaka, H. Seto, Local Dynamics of the Hydration Water and Poly(Methyl Methacrylate) Chains in PMMA Networks, Front. Chem., 9, 728738 (2021). Part of the Research Topic: Interfacial Water: A Physical Chemistry Perspective, Volume II DOI:10.3389/fchem.2021.728738
M. Osaki, S. Yonei, C. Ueda, R. Ikura, J. Park, H. Yamaguchi, A. Harada, M. Tanaka, Y. Takashima, Mechanical Properties with Respect to Water Content of Host-Guest Hydrogels, Macromolecules, 54(17), 8067–8076(2021). DOI:10.1021/acs.macromol.1c00970
T. Ueda, D. Murakami, M. Tanaka, Effect of amount of hydrated water and mobility of hydrated poly(2-methoxyethyl acrylate) on denaturation of adsorbed fibrinogen, J. Polym Sci., 59(22), 2763-2770 (2021). DOI:10.1002/pol.20210496
K. Nishida, T. Anada, S. Kobayashi, T. Ueda, M. Tanaka, Effect of bound water content on cell adhesion strength to water-insoluble polymers, Acta Biomater., 134(15), 313-324(2021). DOI:10.1016/j.actbio.2021.07.058
M. Mabrouk, H.H. Beherei, Y. Tanaka, M. Tanaka, Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass, Int. J. Mol. Sci., 22(15), 8038, (2021). DOI:10.3390/ijms22158038
S. Liu, S. Kobayashi, S. Nishimura, T. Ueda, M. Tanaka, Effect of pendant groups on the blood compatibility and hydration states of poly(2-oxazoline)s, J. Polym Sci., 59(21), 2559-2570 (2021). DOI:10.1002/pol.20210410
R. Anjum, S. Nishimura, S. Kobayashi, K. Nishida, T. Anada, M. Tanaka, Protein Stabilization Effect of Zwitterionic Osmolyte-bearing Polymer, Chem. Lett., 50(9), 1699-1702(2021). DOI:10.1246/cl.210335
M. Yamazaki, Y. Sugimoto, D. Murakami, M. Tanaka, T. Ooya, Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology, Langmuir, 37(28), 8534–8543 (2021). DOI:10.1021/acs.langmuir.1c01003
T. Kanamaru, M. Araki, R. Takahashi, S. Fujii, T. Shikata, D. Murakami, M. Tanaka, K. Sakurai, First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water, J. Phys. Chem. B, 125(26), 7251–7261 (2021). DOI:10.1021/acs.jpcb.1c01864
C. Yoshikawa, S. Hattori, C-F. Huang, H. Kobayashi, M. Tanaka, In vitro and in vivo blood compatibility of concentrated polymer brushes, J. Mater. Chem. B, 9, 5794-5804 (2021). DOI:10.1039/D1TB00886B
S. Liu, S. Kobayashi, T. Sonoda, M. Tanaka, Poly(tertiary amide acrylate) Copolymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States, Biomacromolecules, 22(6), 2718-2728 (2021). DOI:10.1021/acs.biomac.1c0041
A. T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka, Effects of Side-Chain Spacing and Length on Hydration States of Poly(2-methoxyethyl acrylate) Analogues: A Molecular Dynamics Study, ACS Biomater. Sci. Eng., 7(6), 2383-2391 (2021). DOI:10.1021/acsbiomaterials.1c00388
A. Tsujimoto, H. Uehara, H. Yoshida, M. Nishio, K. Furuta, T. Inui, A. Matsumoto, S. Morita, M. Tanaka, C. Kojima, Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density, Mater. Sci. Eng., C, 126, 112159 (2021). DOI:10.1016/j.msec.2021.112159
R. Anjum, K. Nishida, H. Matsumoto, D. Murakami, S. Kobayashi, T. Anada, M. Tanaka, Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials, Coatings, 11(4), 461(2021). DOI:10.3390/coatings11040461
S. Nishimura, T. Ueda, D. Murakami, M. Tanaka, Chain-End Effect for Intermediate Water Formation of Poly(2-Methoxyethyl Acrylate), Organic Materials, 03(02), 214-220(2021). DOI:10.1055/a-1441-8239
T. Sonoda, S. Kobayashi, M. Tanaka, Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization, Macromolecules, 54(6), 2862–2872 (2021). DOI:10.1021/acs.macromol.0c02611
V. Montagna, J. Takahashi, M-Y. Tsai, T. Ota, N. Zivic, S. Kawaguchi, T. Kato, M. Tanaka, H. Sardón, K. Fukushima, Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property, ACS Biomater. Sci. Eng., 7(2), 472–481 (2021). DOI:10.1021/acsbiomaterials.0c01460
Y. Toyokawa, S. Kobayashi, H. Tsuchiya, T. Shibuya, M. Aoki, J. Sumiya, S. Ooyama, T. Ishizawa, N. Makino, Y. Ueno, M. Tanaka, A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition, Mater. Sci. Eng., C, 120, 111386 (2021). DOI: 1016/j.msec.2020.111386
T. Ueda, D. Murakami, M. Tanaka, Effect of interfacial structure based on grafting density of poly(2-methoxyethyl acrylate) on blood compatibility, Colloids Surf., B, 199, 111517 (2021) . DOI:10.1016/j.colsurfb.2020.111517
M. Tanaka, S. Morita, T. Hayashi, Role of interfacial water in determining the interactions of proteins and cells with hydrated materials, Colloids Surf., B, 198, 111449 (2021). DOI:10.1016/j.colsurfb.2020.111449
2020
K. Athanasopulu, D. Caltzidou, A. Sekishita, L. Kutuzova, G. Lorenz, M. Tanaka, R. Kemkemer, Sulfated Hyaluronan coating of polyurethanebased implant materials, Current Directions in Biomedical Engineering, 6(3), 20203115 (2020). DOI:10.1515/cdbme-2020-3115
A.T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka, Molecular Dynamics Study on the Water Mobility and Side-chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s, ACS Biomater. Sci. Eng., 6(12), 6690-6700 (2020). DOI:10.1021/acsbiomaterials.0c01220
T. Sonoda, S. Kobayashi, K. Herai, M. Tanaka, Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity, Macromolecules, 53(19), 8570-8580 (2020). DOI: 10.1021/acs.macromol.0c01144
S. Nishimura, T. Ueda, S. Kobayashi, M. Tanaka, Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties, ACS Appl. Polym. Mater., 2(11), 4790-4801 (2020) (Front Cover in this issue). DOI: 10.1021/acsapm.0c00776
A.T. Kuo, T. Sonoda, S. Urata, R. Koguchi, S. Kobayashi, M. Tanaka, Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement, ACS Biomater. Sci. Eng., 6(7), 3915-3924 (2020). DOI: 10.1021/acsbiomaterials.0c00746
R. Koguchi, K. Jankova, Y. Hayasaka, D. Kobayashi, Y. Amino, T. Miyajima, S. Kobayashi, D. Murakami, K. Yamamoto, M. Tanaka, Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers, ACS Biomater. Sci. Eng., 6(5), 2855-2866 (2020). DOI: 10.1021/acsbiomaterials.0c00230
M-Y. Tsai, F. Aratsu, S. Sekida, S. Kobayashi, M. Tanaka, Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium, ACS Appl. Bio Mater., 3(4), 1858-1864 (2020). DOI: 10.1021/acsabm.9b00885
D. Murakami, Y. Segami, T. Ueda, M. Tanaka, Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers, J. Biomater. Sci. Polym. Ed., 31(2), 207-218 (2020). DOI: 10.1080/09205063.2019.1680930
M. Watanabe, Y. Tanaka, D. Murakami, M. Tanaka, M. Kawai, T. Mitsumata, Optimal Plasticizer Content for Magnetic Elastomers Used for Cell Culture Substrate, Chem. Lett., 49(3), 280-283 (2020). DOI: 10.1246/cl.190929
2019
R. Sakamoto, K. Nakamoto, A. Kitajo, D. Murakami, H. Hirai, M. Tanaka, Y.Zhou, T. Yamaguchi, S. Okada, Highly Concentrated Aqueous Electrolytes for Building High Voltage Aqueous Batteries, The Electrochemical Society of Japan, 87(Autumn), 220-226 (2019). DOI: 10.5796/denkikagaku.19-FE0022
M. Tanaka, S. Kobayashi, D. Murakami, F. Aratsu, A. Kashiwazaki, T. Hoshiba, K. Fukushima, Design of Polymeric Biomaterials: The “Intermediate Water Concept”, Bull. Chem. Soc. Jpn., 92, 2043-2057 (2019). DOI: 10.1246/bcsj.20190274
K. Jankova, I. Javakhishvili, S. Kobayashi, R. Koguchi, D. Murakami, T. Sonoda, M. Tanaka, Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate), ACS Appl. Bio Mater., 2(10), 4154-4161 (2019). DOI: 10.1021/acsabm.9b00363
T. Araki, F. Yoshida, T. Uemura, Y. Noda, S. Yoshimoto, T. Kaiju, T. Suzuki, H. Hamanaka, K. Baba, H. Hayakawa, T. Yabumoto, H. Mochizuki, S. Kobayashi, M. Tanaka, M. Hirata, T. Sekitani, Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires, Adv. Healthcare Mater., 8(10), 1900130 (2019). DOI: 10.1002/adhm.201900130
R. Koguchi, K. Jankova, N. Tanabe, Y. Amino, Y. Hayasaka, D. Kabayashi, T. Miyajima, K. Yamamoto, M. Tanaka, Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate), Biomacromolecules, 20(6), 2265-2275 (2019). DOI: 10.1021/acs.biomac.9b00201
A.-T. Kuo, S. Urata, R. Koguchi, K. Yamamoto, M. Tanaka, Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation, Polymer, 170(29), 76-84 (2019). DOI: 10.1016/j.polymer.2019.03.001
M. Okada, E. Hara, D. Kobayashi, S. Kai, K. Ogura, M. Tanaka, T. Matsumoto, Intermediate Water on Calcium Phosphate Minerals: Its Origin and Role in Crystal Growth, ACS Applied Bio Materials, 2(3), 981-986 (2019). DOI: 10.1021/acsabm.9b00014
D. Murakami, N. Mawatari, T. Sonoda, A. Kashiwazaki, M. Tanaka, Effect of Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility. Langmuir, 35(7), 2808-2813 (2019). DOI: 10.1021/acs.langmuir.8b02971
2018
W. Lee, S. Kobayashi, M. Nagase, Y. Jimbo, I. Saito, Y. Inoue, T. Yambe, M. Sekino, G. G Malliaras, T. Yokota, M. Tanaka, T. Someya, Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping, Sci. Adv., 4(10), eaau2426 (2018). DOI: 10.1126/sciadv.aau2426
T. Ueda, D. Murakami, M. Tanaka, Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface, Front. Chem., 6, 542 (2018). Part of the Research Topic: Polymer Surface Chemistry: Biomolecular Engineering and Biointerfaces DOI: 10.3389/fchem.2018.00542
F. Khan, F. Aratsu, S. Kobayashi, M. Tanaka, A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications, J. Mater. Chem. B, 6(31), 5115-5129 (2018). DOI: 10.1039/C8TB00865E
D. Murakami, Y. Kitahara, S. Kobayashi, M. Tanaka, Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface, ACS Biomater. Sci. Eng., 4, 1591-1597 (2018). DOI: 10.1021/acsbiomaterials.8b00081
M. Mabrouk, H. H. Beherei, S. ElShebiney, M. Tanaka, Newly developed controlled release subcutaneous formulation for tramadol hydrochloride, Saudi Pharmaceutical Journal, 26(4), 585-592 (2018). DOI: 10.1016/j.jsps.2018.01.014
F. Khan, M. Tanaka, Designing Smart Biomaterials for Tissue Engineering, Int. J. Mol. Sci., 19(1), 17 (2018). DOI: 10.3390/ijms19010017
T. Hoshiba, K. Sato, N. Kawazoe, G. CHEN, M. Tanaka, Chondrocyte Shapes and Detachment on a Thermoresponsive Poly(2-methoxyethyl acrylate) Analog for the Development of New Chondrocytes Subculture Substrate, Chem. Lett., 47(1), 107-109 (2018). DOI: 10.1246/cl.170889
2017
S. Kobayashi, M. Wakui, Y. Iwata, M. Tanaka, Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption, Biomacromolecules, 18 (12), 4214-4223 (2017). DOI: 10.1021/acs.biomac.7b01247
K. Fukushima, Y. Inoue, Y. Haga, T. Ota, K. Honda, C. Sato, M. Tanaka, Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents, Biomacromolecules, 18 (11), 3834–3843 (2017). DOI: 10.1021/acs.biomac.7b01210
T. Hoshiba, H. Maruyama, K. Sato, C. Endo, N. Kawazoe, G. Chen, M. Tanaka, Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers, Macromol. Biosci.,17(12),1700297(2017) . DOI: 10.1002/mabi.201700297
K. Fukushima, K. Honda, Y. inoue, M. Tanaka, Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts, Eur. Polym. J., Vol. 95, 728-736 (2017). DOI: 10.1016/j.eurpolymj.2017.07.001
K. Sato, S. Kobayashi, A. Sekishita, M. Wakui, M. Tanaka, Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester): A Candidate for Blood-Compatible Polymers, Biomacromolecules, 18(5), 1609-1616 (2017). DOI: 10.1021/acs.biomac.7b00221
T. Hoshiba, A.Yoshihiro, M. Tanaka, Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers, J. Biomat. Sci. Polym. Ed., 28, 986-999 (2017). DOI: 10.1080/09205063.2017.1312738
T. Sekine, S. Asatyas, C. Sato, S. Morita, M. Tanaka, T. Hayashi, Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: mechanisms underlying the effect of lateral packing density on bioinertness, J. Biomat. Sci. Polym. Ed., 28, 1231-1243 (2017). DOI: 10.1080/09205063.2017.1303120
Y. Inoue, T. Yokota, T. Sekitani, A. Kaneko, T. Woo, S. Kobayashi, T.Shibuya, M. Tanaka, H. Koshukegawa, I. Saito, T. Isoyama, Y. Abe, T.Yambe, T. Someya, M. Sekino, Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime, Ann. Biomed. Eng., 45(5), 1352-1364 (2017). DOI: 10.1007/s10439-016-1781-5
T. Hirata, H. Matsuno, D. Kawaguchi, M. Inutsuka, T. Hirai, M. Tanaka, K. Tanaka, Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy, Phys. Chem. Chem. Phys., 19,1389-1394 (2017). DOI: 10.1039/c6cp07322k
2016
T. Hoshiba, E. Nemoto, K. Sato, H. Maruyama, C. Endo, M. Tanaka, Promotion of Adipogenesis of 3T3-L1 Cells on Protein AdsorptionSuppressing Poly(2-methoxyethyl acrylate) Analogs, Biomacromolecules, 17(11),3808-3815 (2016). DOI:10.1021/acs.biomac.6b01340
D. Murakami, S. Kobayashi, M. Tanaka, Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces, ACS Biomater. Sci. Eng., 2(12), 2122–2126 (2016). DOI:0.1021/acsbiomaterials.6b00415
K. Osawa, S. Kobayashi, M. Tanaka, Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3‑Substituted cis-Cyclooctene, Macromolecules, 49(21), 8154-8161 (2016). DOI:10.1021/acs.macromol.6b01829
T. Hoshiba, M. Tanaka, Integrin-independent Cell Adhesion Substrates: Possibility of Applications for Mechanobiology Research, Anal. Sci., 32(11),1151-1158 (2016). DOI:10.1021/acs.macromol.6b01829
T. Hoshiba, T. Orui, C. Endo, K. Sato, A. Yoshihiro, Y. Minagawa, M.Tanaka, Adhesion-based simple capture and recovery of circulating tumor cells using a blood-compatible and thermo-responsive polymer-coated substrate, RSC Adv., 6, 89103-89112 (2016). DOI:10.1039/C6RA15229E
A. Basterretxea, Y. Haga, A. Sanchez-Sanchez, M. Isik, L. Irusta, M. Tanaka, K. Fukushima, H. Sardon, Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst, Eur. Polym. J., 84, 750-758 (2016). DOI:10.1016/j.eurpolymj.2016.08.008
T. Hoshiba, M.Tanaka, Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels:Mechanism of 5-fluorouracil resistance in colorectal tumor cells, Biochim. Biophys. Acta, Mol. Cell. Res., 1863(11),2749-2757 (2016). DOI:10.1016/j.bbamcr.2016.08.009.
K. Kono, H. Hiruma, S. Kobayashi, Y. Sato, M.Tanaka, R. Sawada, S. Niimi, In Vitro Endothelialization Test of Biomaterials Using Immortalized Endothelial Cells, PLoS One, 11(6), e0158289 (2016). DOI:10.1371/journal.pone.0158289
S. Kobayashi, K. Fukuda, M. Kataoka, M. Tanaka, Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains, Macromolecules, 49(7), 2493-2501 (2016). DOI:10.1021/acs.macromol.6b00273
C. Sato, M. Aoki, M. Tanaka, Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells, Colloids Surf., B,145, 586-596 (2016). DOI:10.1016/j.colsurfb.2016.05.057
T. Hoshiba, M. Nikaido, S.Yagi, I. Konno, A. Yoshihiro, M. Tanaka, Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells, Journal of Bioactive and Compatible Polymers, 31(4), 361-372 (2016). DOI:10.1177/0883911515618976
H. Choi, M. Tanaka, K. Sugimoto, Difference in Cell Proliferation and Spontaneous Mediator Release Between Two Mast Cell Lines, NCL-2 and RBL-2H3 on Honey Comb-like Structured Film, Journal of Nanotechnology: Nanomedicine & Nanobiotechnology, 3(009) (2016). DOI:10.24966/NTMB-2044/100009
T. Hoshiba, G. Chen, C. Endo, H. Maruyama, M. Wakui, E. Nemoto, N. Kawazoe, M. Tanaka. Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation. Stem Cells Int., 2016, 6397820 (2016). DOI:10.1155/2016/6397820
2015
T. Hoshiba, T. Otaki, E. Nemoto, H. Maruyama, M. Tanaka, Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development. ACS Appl. Mater. Interfaces 7(32), 18096-18103 (2015). DOI:10.1021/acsami.5b05210
T. Hirata, H. Matsuno, D. Kawaguchi, N. Yamada, M. Tanaka, K. Tanaka, Construction of a blood-compatible interface based on surface segregation in a polymer blend, Polymer, 78, 219-224 (2015). DOI:10.1016/j.polymer.2015.10.001
F. Khan, M. Tanaka, S.R. Ahmad, Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices, J. Mater. Chem. B, 3, 8224-8249 (2015). DOI:10.1039/C5TB01370D
T. Hoshiba, E. Nemoto, K. Sato, T. Orui, T. Otaki, A. Yoshihiro, M. Tanaka. Regulation of the Contribution of Integrin to Cell Attachment on Poly(2-Methoxyethyl Acrylate) (PMEA) Analogous Polymers for Attachment-Based Cell Enrichment. PLoS One,10(8), e0136066 (2015). DOI:10.1371/journal.pone.0136066
T. Sekine, Y. Tanaka, C. Sato, M. Tanaka, T. Hayashi, Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Monolayers with a Chemical Gradient, Langmuir, 31,7100-7105 (2015). DOI:10.1021/acs.langmuir.5b01216
K. Sato, S. Kobayashi, M. Kusakari, S. Watahiki, M. Oikawa, T. Hoshiba, M. Tanaka, The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues, Macromol. Biosci., 15, 1296-1303 (2015). DOI:10.1002/mabi.201500078
T. Hirata, H. Matsuno, D. Kawaguchi, N. Yamada, M. Tanaka, K. Tanaka, Effect of interfacial structure on bioinert property of poly(2-methoxyethyl acrylate)/ poly(methyl methacrylate) blend films in water, Phys. Chem. Chem. Phys., 17,17399-17405 (2015). DOI:10.1039/c5cp01972a
K. Fukushima, M. Tsai, T. Ota, Y. Haga, K. Matsuzaki, Y. Inoue, M. Tanaka, Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration, Polym. J., 47, 469-473 (2015). DOI:10.1038/pj.2015.22
T. Hirata, H. Matsuno, D. Kawaguchi, T. Hirai, N. Yamada, M. Tanaka, K. Tanaka, Effect of Local Chain dynamics on a Bio-inert Interface, Langmuir, 31, 3661-3667 (2015). DOI:10.1021/acs.langmuir.5b00258
M. Tanaka, K. Sato, E. Kitakami, S. Kobayashi, T. Hoshiba, K. Fukushima, Design of biocompatible and biodegradable polymers based on intermediate water concept, Polymer Journal, 47, 114-121 (2015). Invited paper: Special Issue on Fusion Materials, Most Accessed Papers（September - December 2015） DOI:10.1038/pj.2014.129
T. Hoshiba, M. Tanaka, Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil. Biochem. Biophys.Res. Commun., 457, 353-357 (2015). DOI:10.1016/j.bbrc.2014.12.116
2014
S. Morita, M. Tanaka, Effect of Sodium Chloride on Hydration Structures of PMEA and P(MPC-r-BMA), Langmuir, 30,10698-10703 (2014). DOI:10.1021/la502550d
K. Sugimoto, H. Choi, M. Tanaka, Honeycomb-like structured film regulates mediator release from non-tumor mast cells, European Journal of Inflammation, 12, 515-520 (2014). DOI:10.1177/1721727X1401200313
E. Kitakami, M. Aoki, C. Sato, H. Ishihata, M. Tanaka, Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate), BioMed Resarch International, 2014, 102648 (2014). DOI:10.1155/2014/102648
T. Hoshiba, M. Nikaido, M. Tanaka, Characterization of the Attachment Mechanisms of Tissue-Derived Cell Lines to Blood-Compatible Polymers, Adv. Healthcare Mater., 3, 775-784 (2014). DOI:10.1002/adhm.201300309
H. Choi, M. Tanaka, T. Hiragun, M. Hide, K. Sugimoto, Non-tumor mast cells cultured in vitro on a honeycomb-like structured film prpliferate with multinucleateaed formation, Nanomedicine, 10, 313-319 (2014). DOI:10.1016/j.nano.2013.08.011
J.O. Eniwumide, M.Tanaka, N. Nagai, Y. Morita, J.De Bruijn , S. Yamamoto, S. Onodera, E. Kondo, K. Yasuda, M. Shimomura. The Morphology and Functions of Articular Chondrocytes on a Honeycomb-Patterned Surface, BioMed Research International, 2014, 710354 (2014). DOI:10.1155/2014/710354
2013
M. Birch, M. Tanaka, G. Kirmizidis, S. Yamamoto, M. Shimomura, Microporous "Honeycomb" Films Support Enhanced Bone Formation in Vitro, Tissue Engineering A, 19, 2087-2096, 2013. DOI:10.1089/ten.TEA.2012.0729
T. Hoshiba, M. Tanaka, Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages, Biochemical and Biophysical Research Communications, 439, 291-296, 2013. DOI:10.1016/j.bbrc.2013.08.038
M. Tanaka, T. Hayashi, S. Morita, The roles of water molecule at the biointerface of medical polymers, Polym. J., 45, 701-710, 2013. (Invited paper: SPSJ Asahi Kasei Award). DOI:10.1038/pj.2012.229
2012
T. Hayashi, Y. Tanaka, Y. Koide, M. Tanaka, M. Hara, Mechanism Underlying Bioinertness of Self-assembled Monolayers of Oligo(ethyleneglycol)-terminated Alkanethiols on Gold: Protein Adsorption, Platelet Adhesion, and Surface Forces, Physical Chemistry Chemical Physics, 14,10196-10206, 2012. DOI:10.1039/c2cp41236e
I. Javakhishvili, M. Tanaka, K. Ogura, K. Jankova, S. Hvilsted, Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure, Macromol. Rapid Commun., 33, 319-325, 2012. DOI:10.1002/marc.201100698
T. Hatakeyama, A. Kishi, M. Tanaka, Comparison of measurement techniques for the identification of bound water restrained by polymers, Thermochim Acta, 532, 159-163, 2012. DOI:10.1016/j.tca.2011.01.027
2011
M. Tanaka, Design of Novel 2D and 3D Biointerfaces using Self-Organization to Control Cell behavior, Special issue of Nanotechnologies: Emerging Applications in Biomedicine, Biochimica et Biophysica Acta (BBA) - General Subjects, 1810, 251-258, 2011. DOI:10.1016/j.bbagen.2010.10.002
T. Hirata, H. Matsuno, M. Tanaka, K. Tanaka, Surface Segregation of Poly(2-methoxyethyl acrylate) in a Mixture with Poly(methyl methacrylate), Physical Chemistry Chemical Physics, 13, 4928-4934, 2011. DOI:10.1039/c0cp02101f
Y. Miwa, M. Tanaka, A. Mochizuki, Analyses of Water structures and dynamics of swollen blood compatible polymers, Koubunshi Ronbunshu, 68, 133-146, 2011. DOI:10.1295/koron.68.133
2010
M. Tanaka, A. Mochizuki, Clarification of the Blood Compatibility Mechanism by Controlling the Water Structure at the Blood–Poly(meth)acrylate Interface, J. Biomat. Sci. Polym. Ed., 21, 1849-1863, 2010. DOI:10.1163/092050610X517220
T. Sato, M. Tanaka, S. Yamamoto, E. Ito, K. Shimizu, Y. Igarashi, M. Shimomura, J. Inokuchi, Effect of Honeycomb-Patterned Surface Topography on the Function of Mesenteric Adipocytes, J. Biomat. Sci. Polym. Ed., 21, 1947-1956, 2010. DOI:10.1163/092050610X500615
S. Morita, M. Tanaka, K. Kitagawa, Y. Ozaki, Hydration structure of poly(2-methoxyethyl acrylate): comparison with a 2-methoxyethyl acetate model monomer, J. Biomat. Sci. Polym. Ed., 21, 1925-1935, 2010. DOI:10.1163/092050610x494613
Y. Miwa, H. Ishida, M. Tanaka, A. Mochizuki, 2H-NMR and 13C-NMR Study of the Hydration Behavior of Poly(2-methoxyethyl acrylate), Poly(2-hydroxyethyl methacrylate) and Poly(tetrahydrofurfuryl acrylate) in Relation to Their Blood Compatibility as Biomaterials, J. Biomat. Sci. Polym. Ed., 21, 1911-1924, 2010. DOI:10.1163/092050610X489682
T. Hatakayama, M. Tanaka, H. Hatakayama, Thermal Properties of Freezing Bound Water Restrained by Polysaccharides, J. Biomat. Sci. Polym. Ed., 21, 1865-1875, 2010. DOI:10.1163/092050610X486946
A. Mochizuki, M. Kimura, A. Ina, Y. Tomono, M.Tanaka, Study on water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate), J. Biomat. Sci. Polym. Ed., 21, 1895-1910, 2010. DOI:10.1163/092050610X489321
T. Hatakayama, M. Tanaka, H. Hatakayama, Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC): Comparison of the polysaccharides-water systems, Acta Biomaterialia, 6, 2077-2082, 2010. DOI:10.1016/j.actbio.2009.12.018
H. Ishihata, M. Tanaka, N. Iwama, M. Ara, M. Shimonishi, M. Nagamine, N. Murakami, S. Kanaya, E. Nemoto, H. Shimauchi, M. Shimomura, Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization, Journal of Biomechanical Science and Engineering, Special Issue on Micro and Nanobiotechnology for Cells, 5, 252-261, 2010. DOI:10.1299/jbse.5.252
Y. Uraki, C. Matsumoto, T. Hirai, Y. Tamai, M. Enoki, H. Yabu, M. Tanaka, M. Shimomura, Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films, Journal of Wood Chemistry and Technology, 30, 348-359, 2010. DOI:10.1080/02773811003746709
2009
M. Tanaka, M. Takebayashi, M. Shimomura, Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned film, Macromol .Symp., (Invited original paper). 279, 175-182, 2009. DOI:10.1002/masy.200950527
M. Tanaka, H. Sato, Y. Sasaya, S. Horinouchi, J. Hotta, Y. Matsuo, K. Ijiro, K. Sasaki, M. Shimomura, Fabrication of Novel Biocompatible Surfaces by Two-Photon Absorption Technique Using Femtosecond Laser, Mol. Cryst. Liq. Cryst., 505, 219-230, 2009. DOI:10.1080/15421400902950121
Y. Miwa, H.Ishida, H.Saitô, M. Tanaka, A. Mochizuki, Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR, Polymer, 50, 6091- 6099, 2009. DOI:10.1016/j.polymer.2009.10.037
A. Mochizuki, T. Hatakeyama, Y. Tomono, M. Tanaka, Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate). J. Biomat. Sci. Polym. Ed., 20, 591-603, 2009. DOI:10.1163/156856209x426411
A. Mochizuki, A. Kishi, M. Tanaka, Comparative study on water structures in polyHEMA and polyMEA by XRD-DSC simultaneous measurement, J. Appl. Poly. Sci., 111, 476-481, 2009. DOI:10.1002/app.29127
Y. M. Chen, J. P. Gong, M. Tanaka, K. Yasuda, S. Yamamoto, M. Shimomura, Y. Osada, Tuning of cell proliferation on tough gels by critical charge effect, J. Biomed. Mater. Res. A, 88A, 74-83, 2009. DOI:10.1002/jbm.a.31869
S. Tada, C. Inaba, K. Mizukami, S. Fujishita, M. Gemmei-Ide, H. Kitano, A. Mochizuki, M. Tanaka, T. Matsunaga, Anti-Biofouling Properties of Polymers with a Carboxybetaine Moiety. Macromolecular Bioscience, 9(1), 63-70, 2009. DOI:10.1002/mabi.200800150
2008
M. Tanaka, K. Yoshizawa, A. Tsuruma, H. Sunami, S. Yamamoto, M. Shimomura, Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 313-314, 515-519, 2008. DOI:10.1016/j.colsurfa.2007.05.081
K Arai, M. Tanaka, S. Yamamoto, M. Shimomura, Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 313-314, 530-535, 2008. DOI:10.1016/j.colsurfa.2007.04.128
A. Tsuruma, M. Tanaka, S. Yamamoto, M. Shimomura, Control of neural stem cell differentiation on honeycomb films, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 313-314, 536-540, 2008. DOI:10.1016/j.colsurfa.2007.05.079
A. Tanabe, S. Morita, M. Tanaka, I. Noda, Y. Ozaki, Multivariate Curve Resolution Analysis on Multi-Component Water Sorption Process into a Poly(2-methoxyethyl acrylate) Film, Appl. Spec., 62, 46-50, 2008. DOI:10.1366/000370208783412555
H. Kitano, K. Nagaoka, S. Tada, M. Gemmei-Ide, M. Tanaka, Structure of Water Incorporated in Amphoteric Polymer Thin Films as Revealed by FT-IR Spectroscopy, Macromolecular Bioscience, 8, 77-85, 2008. DOI:10.1002/mabi.200700082
Y. Fukuhira, M. Ito, H. Kaneko, Y. Sumi, M. Tanaka, S. Yamamoto, M. Shimomura, Prevention of postoperative adhesions by honeycomb-patterned poly(lactide)film in rat experimental model, J. Biomed. Mater. Res. B, 86B, 353-359, 2008. DOI:10.1002/jbm.b.31026
A. Nogami, E. Tominaga, Y. Sawa, T. Murata, Y. Kudo, M.Tanaka, M.Shimomura, Development of the honeycomb film filter for individual aerosol particle analysis, Earozoru Kenkyu, 23(2), 127-133, 2008. DOI:10.11203/jar.23.127
S. Tsukiyama, M. Matsushita, M. Tanaka, H. Tamura, S. Todo, S. Yamamoto, M. Shimomura, Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films, Jp. J. Appl. Phys., Vol. 47, No. 2, 1429-1434, 2008. DOI:10.1143/JJAP.47.1429
Y. Fukuhira, H. Kaneko, M. Yamaga, M. Tanaka, S. Yamamoto, M. Shimomura, Effect of honeycomb-patterned structure on chondrocyte behavior in vitro, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 313-314, 520-525, 2008. DOI:10.1016/j.colsurfa.2007.05.047
2007
M. Tanaka, A. Takayama, E. Ito, H. Sunami, S. Yamamoto M. Shimomura, Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells, J. Nanosci. Nanotech., 7, 763-772, 2007. DOI:10.1166/jnn.2007.514
S. Yamamoto, M. Tanaka, E. Ito, Y. Morita , H. Sunami, K. Ijiro, M. Shimomura, The influence of pore size of a honeycomb film on early spreading process of endtherial cells, J. Surf. Sci. Soc. Jap., 28(8), 433-439, 2007. DOI:10.1380/jsssj.28.433
T. Okajima, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto, Stress Relaxation and Fluctuation of Living Cells Measured by Atomic Force Microscopy, Jp. J. Appl. Phys., 46 (8B), 5552-5555, 2007. DOI:10.1143/JJAP.46.5552
S. Yamamoto, M. Tanaka, H. Sunami, S. Yamashita, Y. Morita, M. Shimomura, Effects of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells, Langmuir, 23, 8114-8120, 2007. DOI:10.1021/la700332610.1021/la7003326
J.R. McMillan, M. Akiyama, M. Tanaka, S. Yamamoto, M. Goto, R. Abe, D. Sawamura, M. Shimomura, H. Shimizu, Small-diameter porous poly (epsilon-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells., Tissue Engineering, 13, 789-798, 2007. DOI:10.1089/ten.2006.0321
Y. M. Chen, M. Tanaka, JP Gong, K Yasuda, S. Yamamoto, M. Shimomura, Y. Osada, Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds, Biomaterials, 28, 1752-1760, 2007. DOI:10.1016/j.biomaterials.2006.12.005
T. Okajima, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto, Stress relaxation of HepG2 cells measured by atomic force microscopy, Nanotechnology, 18, 084010-4, 2007. DOI:10.1088/0957-4484/18/8/084010
S. Morita, M. Tanaka, Y. Ozaki, Time-Resolved In-Situ ATR-IR Observations of Water Sorption Process into a Poly(2-methoxyethyl acrylate) (PMEA) Film, Langmuir, 23, 3750-3761, 2007. DOI:10.1021/la0625998
T. Hayashi, M. Tanaka, S. Yamamoto, M. Shimomura, M. Hara, Direct observation of biocompatibility of PMEA(poly(2-methoxyethyl acrylate)) using Atomic Force Microscopy, Biointerphases, 2(4), 1-9 , 2007. DOI:10.1116/1.2794712
S. Morita, M. Tanaka, I. Noda, Y. Ozaki, Phase Angle Description of Perturbation Correlation Analysis and Its Application to Time-Resolved IR Spectra, Appl. Spec.,61(8), 867-872, 2007. DOI:10.1366/000370207781540051
E. Hirota, M. Tanaka, A. Mochizuki, Blood Compatibility and Water Structure-Comparative Study between 2-Methoxyethylacrylate- and 2-Methoxyethylmethacrylate-based random copolymers, J. Biomed. Mater. Res. 81A, 710-719, 2007. DOI:10.1002/jbm.a.31113
Y. Uraki, J. Nemoto, H. Otsuka, Y. Tamai, J. Sugiyama, T. Kishimoto, M. Ubukata, H. Yabu, M. Tanaka, M. Shimomura, Honeycomb-Like Architecture Produced by Living Bacteria, Gluconacetobacter xylinus, Carbohydrate Polymers, 69, 1-6, 2007. DOI:10.1016/j.carbpol.2006.08.021
T. Hatakeyma, H. Kasuga, M. Tanaka, H. Hatakeyama, Cold crystallization of poly(ethylene glycol)-water systems, Thermochim Acta, 465, 59-66, 2007. DOI:10.1016/j.tca.2007.09.005
2006
S. Yamamoto, M. Tanaka, H. Sunami, S. Yamashita, Y. Morita, M. Shimomura, Relationship between adsorbed fibronectin and cell adhesion on a honeycomb-patterned film, Surf. Sci., 600, 3785-3791, 2006. DOI:10.1016/j.susc.2006.01.085
M. Tanaka, K. Nishikawa, H. Okubo, H. Kamachi, T. Kawai, M. Matsushita, S. Todo, M. Shimomura, Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 284-285, 464-469, 2006. DOI:10.1016/j.colsurfa.2005.11.098
A. Tsuruma, M. Tanaka, S. Yamamoto, N. Fukushima, H. Yabu, M. Shimomura, Topographical control of neurites extension on stripe-patterned polymer films, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 284-285, 470-474, 2006. DOI:10.1016/j.colsurfa.2005.11.100
S. Yamamoto, M. Tanaka, H. Sunami, S. Yamashita, Y. Morita, M. Shimomura, Relationship between Adsorbed Fibronectin and Cell Adhesion on a Honeycomb-patterned Film, J. Surf. Sci. Soc. Jap., 27(10), 2006. DOI:10.1380/jsssj.27.502
H. Sunami, E. Ito, M. Tanaka, S.Yamamoto, M. Shimomura, Effect of honeycomb film on protein adsorption, cell adhesion and proliferation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 284-285, 548-551, 2006. DOI:10.1016/j.colsurfa.2005.11.041
Y. Fukuhira, E. Kitazono, T. Hayashi, H. Kaneko, M. Tanaka, M. Shimomura, Y. Sumi, Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine, Biomaterials, 27, 1797-1802, 2006. DOI:10.1016/j.biomaterials.2005.10.019
E. Hirota, K. Ute, M. Uehara, T. Kitayama, M. Tanaka, A. Mochizuki, -Study of Blood Compatibility with Poly(2-Methoxyethylacrylate) - Relationship between Surface Structure, Water Structure and Platelet Compatibility in 2-Methoxyethylacrylate/2-Hydroxyethylmethacrylate Diblock Copolymer, J. Biomed. Mater. Res., 76A, 540-550, 2006. DOI:10.1002/jbm.a.30563
M. Shimomura, A. Tsuruma, M. Tanaka, H. Sunami, S. Yamamoto, Biomedical application of patterned polymer films prepared by self-organization, J. Surf. Sci. Soc. Jap., 27, 170-175, 2006. DOI:10.1380/jsssj.27.170
2005
A. Tsuruma, M. Tanaka, N. Fukushima, M. Shimomura, Morphological changes in neurons by self-organized patterned films, e-J. Surf. Sci. Nanotech., 3, 159-164, 2005. DOI:10.1380/ejssnt.2005.159
H. Kitano, T. Mori, Y. Takeuchi, S. Tada, M. Gemmei-ide, Y. Yokoyama, M. Tanaka, Structure of Water Incorporated in Sulfobetaine Polymer Films as Studied by ATR-FTIR, Macromol. Biosci., 5(4), 314-321, 2005. DOI:10.1002/mabi.200400212
J. Nemoto, Y. Uraki, T. Kishimoto, Y. Sano, R. Funada, N. Obata, H. Yabu, M. Tanaka, M. Shimomura, Production of mesoscopically patterned cellulose film, Bioresource Technol, 96(17), 1955-1958, 2005. DOI:10.1016/j.biortech.2005.01.034
H. Kitano, S. Tada, T. Mori, K. Takaha, M. Gemmei-Ide, M. Tanaka, M. Fukuda, Y. Yokoyama, Correlation between the Structure of Water in the Vicinity of Carboxybetaine Polymers and Their Blood-Compatibility, Langmuir, 21, 11932-11940, 2005. DOI:10.1021/la0515571
H. Yabu, M. Takebayashi, M. Tanaka, M. Shimomura, Superhydrophobic and Lipophobic Properties of Self-Organized Honeycomb and Pincushion Structures, Langmuir, 21(8), 3235-3237, 2005. DOI:10.1021/la050013w
2004年以前
M. Tanaka, A. Mochizuki, Effect of water structure on blood compatibility－Thermal analysis of water in poly(meth)acrylate－, J. Biomed. Mater. Res., 68A(3), 684-695, 2004. DOI:10.1002/jbm.a.20088
M. Tanaka, Design of Novel BioInterfaces (I) -Blood compatibility of poly(2-methoxyethyl acrylate)-, Bio-Med. Mater. Eng., 14, 427-438, 2004. [HTML]
M. Tanaka, M. Takebayashi, M. Miyama, J. Nishida, M. Shimomura, Design of Novel BioInterfaces (II) -Fabrication of self-organized porous polymer film with highly uniform pores-, Bio-Med. Mater. Eng., 14, 439-446, 2004. [HTML]
G. Li, S. Morita, S. Ye, M. Tanaka, M. Osawa, Bisphenol QCM and IRRAS Characterization of Bisphenol A Absorption in the Poly(acrylate) Thin Films, Anal. Chem.76, 788-795, 2004. DOI:10.1021/ac0348874
A. Tsuruma, M. Tanaka, N. Fukushima, M. Shimomura, Control of neurites extension by self-organized patterned polymer films, Koubunshi Ronbunshuu, 61(12), 628-633, 2004. [PDF]
M. Ide, T. Mori, K. Ichikawa, H. Kitano, M.Tanaka, A. Mochizuki, H. Oshiyama, W. Mizuno, Structure of Water Sorbed into Poly(MEA-co-HEMA) Films As Examined by ATR-IR Spectroscopy, Langmuir, 19, 429-435, 2003. DOI:10.1021/la020617p
M. Tanaka, Blood Compatibility of Poly(2-methoxyethyl acrylate) - Design of Novel Biointerfaces, Koubunshi Ronbunshuu, 60(8), 415-427, 2003. DOI:10.1295/koron.60.415
S. Ye, S. Morita, G. Li, H. Noda, M. Tanaka, K. Uosaki, M. Osawa, Interfacial Molecular Structure Changes in Poly(2-methoxyethyl acrylate) Thin Films Induced by Absorption of Bisphenol A. An Infrared and Sum Frequency Generation (SFG) Study, Macromolecules, 36, 5694-5703, 2003. DOI:10.1021/ma026007d
H. Yabu, M. Tanaka, K. Ijiro, M. Shimomura, Preparation of honeycomb patterned polyimide films by self-organization, Langmuir, 19, 6297-6300, 2003. DOI:10.1021/la034454w
M. Tanaka, A. Mochizuki, N. Ishii, T. Motomura, T. Hatakeyama, Study of Blood Compatibility With poly(2-methoxyethyl Acrylate). Relationship Between Water Structure and Platelet Compatibility in poly(2-methoxyethylacrylate-co- 2-hydroxyethylmethacrylate), Biomacromolecules, 3, 36-41, 2002. DOI:10.1021/bm010072y
M. Tanaka, A. Mochizuki, T. Shiroya, T. Motomura, K. Shimura, M. Onishi, Y. Okahata, Study on kinetics of early stage protein adsorption on poly(2-methoxyethylacrylate) (PMEA) surface. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 203, 195-204, 2002. DOI:10.1016/S0927-7757(01)01100-1
K. Sato, M. Tanaka, K. Hasebe, M. Takebayashi, K. Nishikawa, T. Kawai, M. Matsushita, S. Todo, M. Shimomura, Preparation of the honeycomb patterned porous film of biodegradable polymer for tissue engineering scaffolds, Inter. J. Nanosci., 1(5,6), 689-693, 2002. DOI:10.1142/9789812796714_0055
M.Tanaka, A. Mochizuki, T. Motomura, K. Shimura, M. Onishi, Y. Okahata. In Situ Studies on Protein Adsorption onto a Poly(2-methoxyethyl acrylate) Surface by a Quartz Crystal Microbalance. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 193, 145-152, 2001. DOI:10.1016/S0927-7757(01)00682-3
H. Kitano, K. Ichikawa, M. Fukuda, A. Mochizuki, M. Tanaka, The Structure of Water Sorbed to Polymethylmethacrylate Film As Examined by FT-IR Spectroscopy, J. Colloid Surface Sci., 242, 133-140, 2001. DOI:10.1006/jcis.2001.7785
K. Ichikawa, T. Mori, H. Kitano, M. Fukuda, A. Mochizuki, M. Tanaka, A FT-IR Study on the Sorption of Water to Various Kinds of Polymer Thin Films, J. Polym. Sci., B Polym. Phys. 39, 2175-2182, 2001. DOI:10.1002/polb.1191
L. Schiel, S. Burns, A. Nogawa, R. Rice, T. Anzai, M. Tanaka, X-Coating : A New Biopassive Polymer Coating, Canadian Perfusion Canadienne, 11(2), 8-17, 2001. [PDF]
M. Tanaka, T. Motomura, N. Ishii, K. Shimura, M. Onishi, A. Mochizuki, T. Hatakeyama, Cold crystallization of water in hydrated Poly(2-methoxyethyl acrylate) (PMEA), Polymer International, 49, 1709-1713, 2000. DOI:10.1002/1097-0126(200012)49:12<1709::AID-PI601>3.0.CO;2-L
M. Tanaka, T. Motomura, M. Kawada, T. Anzai, Y. Kasori, T. Shiroya, K. Shimura, M. Onishi, A. Mochizuki, Y. Okahata, A new blood-compatible surface prepared by Poly(2-methoxyethyl acrylate) (PMEA) coating -Protein adsorption on PMEA surface-, Jpn. J.Art. Org, 29, 209-216, 2000. DOI:10.11392/jsao1972.29.209
M. Tanaka, T. Motomura, M. Kawada, T. Anzai, Y. Kasori, T. Shiroya, K. Shimura, M. Onishi, A. Mochizuki, Blood compatible aspects of Poly(2-methoxyethylacrylate) (PMEA) -Relationship between protein adsorption and platelet adhesion on PMEA surface-, Biomaterials, 21, 1471-1481, 2000. DOI:10.1016/S0142-9612(00)00031-4
M.Shimomura, F.Nakamura, K.Ijiro, H.Taketsuna, M.Tanaka, H.Nakamura, K.Hasebe, Two-dimrnsional DNA-mimetic monolayer organization at the air-water interface, J. Am. Chem. Soc., 119, 2341-2342, 1997. DOI:10.1021/ja962847u
K.Ijiro, M.Shimomura, M.Tanaka, H.Nakamura, K.Hasebe, DNA monolayers complexed with amphiphilic intercalator at the air water interface, Thin Solid Films, 284-285, 780-783, 1996. DOI:10.1016/S0040-6090(95)08445-2
