A New Neurovascular Stent Developed from Our Research on Intermediate Water

2024/12/09

Our laboratory’s research on intermediate water has led to the development and commercialization of an innovative neurovascular stent.
https://medical.terumo.co.jp/equipment/neuroendovascular-intervention/me417
FRED™ X | MicroVention

Reference paper:
C. Sato, M. Aoki, M. Tanaka, Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells, Colloids Surf., B,145, 586-596 (2016).
DOI:10.1016/j.colsurfb.2016.05.057
S. Nishimura, M. Tanaka, The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update, Bull. Chem. Soc. Jpn., 96(9), 1052-1070 (2023) .
Account/Review for Memorial Collection for CSJ/OUP Co-Operative Publication
Account/Review for Controlled Chemical Construction (C3) for Advanced Functions
DOI : 10.1246/bcsj.20230168
J. Park, T. Ueda, Y. Kawai, K. Araki, M. Kido, B. Kure, N. Takenaka, Y. Takashima, M. Tanaka, Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate, RSC Advances, 12(43), 27912-27917 (2022).
DOI:10.1039/d2ra04885j
M. A. Haque, D. Murakami, M. Tanaka, Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel, Surfaces, 5(3), 365-382 (2022).
DOI:10.3390/surfaces5030027
M. A. Haque, D. Murakami, T. Anada, M. Tanaka, Poly(2-Methoxyethyl Acrylate) (PMEA)-Coated Anti-Platelet Adhesive Surfaces to Mimic Native Blood Vessels through HUVECs Attachment, Migration, and Monolayer Formation, Coatings, 12(6), 869 (2022).
DOI:10.3390/coatings12060869
K. Nishida, T. Anada, M. Tanaka, Roles of interfacial water states on advanced biomedical material design, Adv. Drug Delivery Rev., 186, 114310 (2022).
DOI:10.1016/j.addr.2022.114310
K. Nishida, T. Anada, S. Kobayashi, T. Ueda, M. Tanaka, Effect of bound water content on cell adhesion strength to water-insoluble polymers, Acta Biomater., 134(15), 313-324(2021).
DOI:10.1016/j.actbio.2021.07.058
R. Anjum, K. Nishida, H. Matsumoto, D. Murakami, S. Kobayashi, T. Anada, M. Tanaka, Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials, Coatings, 11(4), 461(2021).
DOI:10.3390/coatings11040461
M. Tanaka, S. Morita, T. Hayashi, Role of interfacial water in determining the interactions of proteins and cells with hydrated materials, Colloids Surf., B, 198, 111449 (2021).
DOI:10.1016/j.colsurfb.2020.111449
S. Nishimura, T. Ueda, S. Kobayashi, M. Tanaka, Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties, ACS Appl. Polym. Mater., 2(11), 4790-4801 (2020) (Front Cover in this issue).
DOI: 10.1021/acsapm.0c00776
M. Tanaka, S. Kobayashi, D. Murakami, F. Aratsu, A. Kashiwazaki, T. Hoshiba, K. Fukushima, Design of Polymeric Biomaterials: The “Intermediate Water Concept”, Bull. Chem. Soc. Jpn., 92, 2043-2057 (2019).
DOI: 10.1246/bcsj.20190274
F. Khan, M. Tanaka, Designing Smart Biomaterials for Tissue Engineering, Int. J. Mol. Sci., 19(1), 17 (2018).
DOI: 10.3390/ijms19010017
K. Fukushima, Y. Inoue, Y. Haga, T. Ota, K. Honda, C. Sato, M. Tanaka, Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents, Biomacromolecules, 18 (11), 3834–3843 (2017).
DOI: 10.1021/acs.biomac.7b01210
M. Tanaka, K. Sato, E. Kitakami, S. Kobayashi, T. Hoshiba, K. Fukushima, Design of biocompatible and biodegradable polymers based on intermediate water concept, Polymer Journal, 47, 114-121 (2015). Invited paper: Special Issue on Fusion Materials, Most Accessed Papers（September – December 2015）
DOI:10.1038/pj.2014.129
T. Hoshiba, M. Nikaido, M. Tanaka, Characterization of the Attachment Mechanisms of Tissue-Derived Cell Lines to Blood-Compatible Polymers, Adv. Healthcare Mater., 3, 775-784 (2014).
DOI:10.1002/adhm.201300309
M. Tanaka, T. Hayashi, S. Morita, The roles of water molecule at the biointerface of medical polymers, Polym. J., 45, 701-710, 2013. (Invited paper: SPSJ Asahi Kasei Award).
DOI:10.1038/pj.2012.229
S. Nishimura, N. Kurahashi, S. Shiomoto, Y. Harada, M. Tanaka, Effects of Hydration Water on Bioresponsiveness of Polymer Interfaces Revealed by Analysis of Linear and Cyclic Polymer–Grafted Substrates, Soft Matter, in press (2024).
DOI：10.1039/D4SM00977K